Bitter Melon Reduces Head and Neck Squamous Cell Carcinoma Growth by Targeting c-Met Signaling

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Bitter Melon Reduces Head and Neck Squamous Cell Carcinoma Growth by Targeting c-Met Signaling

Head and neck squamous cell carcinoma (HNSCC) remains difficult to treat, and despite of advances in treatment, the overall survival rate has only modestly improved over the past several years. Thus, there is an urgent need for additional therapeutic modalities. We hypothesized that treatment of HNSCC cells with a dietary product such as bitter melon extract (BME) modulates multiple signaling p...

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Despite advances in surgical and medical therapies, approximate 50% survival rate of head and neck squamous cell carcinoma (HNSCC) has had marginal improvement in the last 30 years. Therefore, alternative strategies are required for the management of HNSCC. Here, we report the chemotherapeutic effect of proanthocyanidins on HNSCC cells using in vitro and in vivo models. Treatment of human HNSCC...

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HGF and c-MET as potential orchestrators of invasive growth in head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) constitutes 90% of all head and neck cancers and is associated with high mortality rates, due to the high infiltrative potential of these tumors. Despite advances in treatment approaches, there has been no improvement in survival rates. As empiricism in the treatment of HNSCC is unlikely to improve the prognosis of HNSCC patients, understanding the ...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2013

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0078006